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Clinical Pharmacy

The PM Problem: Is Diphenhydramine Actually Good for Sleep?

Diphenhydramine may cause drowsiness, but rapid tolerance, limited insomnia benefits, and anticholinergic risks make it a poor long-term sleep solution.

  • Ricky Jobe, PharmD Candidate

Ricky Jobe, PharmD Candidate

09 Sep 2026 • 6 min read
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The PM Problem: Is Diphenhydramine Actually Good for Sleep?
Cover image source: https://www.tylenol.com/products/sleep-pain/tylenol-pm-extra-strength-caplet

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GI Malignancies: Pancreatic Cancer

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